Javelin Pharmaceuticals

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PMI-150 (intranasal ketamine)

Ketamine, a non-opiate, is an N-methyl-D-aspartate (“NMDA”),
receptor antagonist that has been in clinical use for over 30 years as
a general anesthetic. Since its approval by the FDA, ketamine has been
safely used as an anesthetic in tens of thousands of patients. NMDA receptors
are located in the central nervous system and play a role in the perception
of acute and chronic pain. Ketamine blocks NMDA receptors and therefore
is a logical drug candidate for use as an analgesic for syndromes associated
with acute pain, as well as breakthrough pain. Ketamine, at lower doses
than that approved for use as an anesthetic, has been reported in the
medical literature to be an effective medication for the treatment of
postoperative pain, neuropathic pain and pain during emergency medical
procedures.

Javelin has a developed PMI-150, a proprietary nasal formulation
of ketamine which is currently under development for treatment of acute
moderate-to-severe pain. The Company believes that PMI-150 is optimized
for use as a pain medication and may offer a safe, non-opioid alternative
for the treatment of moderate-to-severe pain.

Previous randomized, double-blinded, placebo-controlled
phase II clinical studies have demonstrated statistically significant
(p<0.05) relief of moderate to severe post-operative and breakthrough
pain. PMI-150 was fast-acting, with statistically significant (p<0.05)
pain relief occurring as early as 4 minutes post administration of PMI-150.
PMI-150 also appeared to be safe and well-tolerated by patients. These
results were presented at the American Society for Clinical Pharmacology
and Therapeutics in Atlanta, Georgia in April 2002 and the American Society
of Clinical Oncology in Orlando, Florida in May 2002. In May 2003, following
the presentation of clinical data at the plenary session of the Advanced
Technology Application for Combat Casualty Care conference in Orlando,
Florida, the U.S. Department of Defense awarded a $4 million funding
extension to IDDS to aid in the development of PMI-150. This award is
based on the need of the military for a fast-acting, non-invasive, and
non-sedating alternative to the intravenous and oral medications commonly
used for treatment of combat-related injuries. In June 2004, the company
attended the End-of-Phase II meeting with representatives of the U.S.
Food and Drug Administration (FDA). In August 2005, Javelin presented
a meta-analysis of three randomized, placebo-controlled studies involving
ketamine analgesia for patients with acute moderate-to-severe pain. The
results of the meta-analysis demonstrated that intranasal ketamine was
effective at relieving moderate-to-severe pain over the 10 to 50 mg dose
range with no statistically significant changes to vital signs or arterial
oxygen saturation levels. These data were presented at the Department
of Defense’s premier medical conference, the Advanced Technology
Application for Combat Casualty Care in St. Petersburg, Florida.

 

* OPERATINGВ PRINCIPLES

G E N E R A L    O P E R A T I N G    P R I N C I P L E S

proposed   OPERATIONAL   STATEMENT   #001-00

 

   

 

PURPOSE

This Operational Statement creates the process by which the Board of Trustees delegates authority to the Regional Councils, District Coalitions, Local Healthcare Communities, Officers and employees of  NATIONAL  HEALTH.   This process is based on a Derivative Concept of governance, the delegation of authority within a corporate entity.  The Derivative Concept recognizes the Board of Trustees as having the ultimate authority for the affairs of  NATIONAL  HEALTH  as granted to it by the Congressional Charter.  To implement the purposes of  NATIONAL  HEALTH,   the Board of Trustees may grant limited authority and or responsibility to the Regional Councils, District Coalitions, Local Healthcare Communities, Officers or employees for certain specific TASKS.  Throughout its existence, the Board of Trustees retains for itself any remaining authority. 

As a means to formalize the Derivative Concept of governance,  this Operational Statement establishes the basis for all Policies and Procedures of  NATIONAL  HEALTH.  The structure and content of these Operational Statement is intended to ensure that the delegation of authority is consistent with the Congressional Charter granted to  NATIONAL  HEALTH  as well as any other applicable Federal, State or local statutes

 

TASKS

 

I.  ORGANIZE  SYSTEMS

          A.  Prepare all OPERATIONAL STATEMENTS  for Policies and their related Procedures according to a uniform format

II.  PURSUE   V I S I O N

          A.  Establish the Authority for any  OPERATIONAL  STATEMENT  during an appropriate Meeting of the Board of Trustees

          B.  Maintain a Strategic Development Plan, annually revised, as a means to implement the Congressional Charter

III.  BUILD  TRADITION

          A.  Maintain a directory for all  OPERATIONAL  STATEMENTS  including the specific authority for their approval, responsible or affected positions and provisions for their revision or review. 

IV.  MANAGE RESOURCES

          A.  Maintain an Integrated Financial Plan for the Strategic Development Plan

          B.  Maintain a Risk Management Plan for the prevention or management of operational conditions potentially threatening the fundamental execution of the Strategic Development Plan 

V.  DEVELOP  SKILLS

          A.  Maintain the appropriate support for any external audit as may be commissioned by the Board of Trustees or required by legal or contractual obligations

          B.  Maintain an internal audit for an annual review by the Board of Trustees regarding implementation of the Strategic Development Plan

          C. Improve the professional assets of all committee Members and employed staff

Massage Therapy

After an initial consultation I will create a specific massage treatment plan to meet your needs and goals. I also offer exercise plans geared towards correcting postural and muscle imbalances in the body.

Remedial massage

Postural/injury assessment followed by a treatment to help the body recover from injury and re-align posture. This is a deep massage used to treat strains, sprains or many other common injuries.  It also speeds up recovery and encourages more complete healing. Remedial massage is also used for conditions created by lifestyle such as Repetitive strain injury and Back pain.
It uses many advanced massage techniques such as myofascial stripping, trigger point therapy and PNF stretching.  I often find it is successful where many other types of treatments have failed

Sports massage

Pre and post exercise treatment consists of specific techniques aimed at preparing the body for exercise and helping it recover afterwards. Other aspects of sports massage are similar to remedial and Swedish massage techniques. It is important to have a sports massage regularly if you exercise 3 times a week or more to keep your body flexible and healthy.  It hugely benefits your training and will help you achieve your fitness goals.

DB Full Body MOT

This is our signature treatment which is specific for all health and fitness fans. Whether you are a beginner or an advanced trainer, you will get great benefits from an MOT. The main benefits are injury prevention, recovery and increased flexibility. This treatment incorporates Deep tissue and PNF stretching with 3 spinal mobilisation techniques leaving you feeling invigorated and ready to take on the gym again!

Monthly membership package

You will receive any 2 treatments per month of your choosing at this discounted rate. If you book for 4 months consecutively then you’ll also receive a FREE treatment for your customer loyalty. If you wish any additional treatments they will also be at the discounted rate of £30 per session.

Developmental Evaluation

Parents and pediatricians with concerns about a child’s development can take advantage of the evaluation services available through Sutter Women’s and Children’s Services. Early testing can often determine developmental issues or underlying conditions that are affecting a child’s development. Tests are designed to match the abilities and expectations of children of all ages, from passive infant evaluations to complex testing of teenagers. Test results are shared with parents, referring physicians and specialists with expertise in the areas of concern. Once concerns are pinpointed, causes and treatments can follow.

In addition to physical issues, Sutter offers the only community-based, not-for-profit hospital-affiliated program of mental health services for children of all ages. When needed, evaluations by psychologists and psychiatrists who specialize in children’s issues can help locate underlying concerns and determine treatment options.

For more information about the development evaluation services available, please contact (916)733-1025. To find out more about ” and “, as well as other “, please visit our health information section of this website.


10 ways in which to eat healthy.

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1. feeding breakfast could be a basic behavior that have an effect on the mind. And vitality to your life throughout the day. And facilitate scale back blood sterol levels. scale back the danger of heart condition. facilitate improve metabolism. the opposite meals you eat less.

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7. Classified themselves as tea, black tea, tea leaf or garage Earl grey. All have inhibitor properties. Tea drinking one to three cups on a daily basis reduces the danger of abdomen cancer by half-hour.

8. Feed for all things natural. you would like to eat a spread of colourful fruits and vegetables like tomatoes, red and purple grapes, inexperienced block Keri orange carrot not stick to something to eat alone. the various coloured plants. There square measure differing types of nutrients. It conjointly adds color to eat you with.

9th. reworked himself into a fish lover. feeding fish a minimum of once per week. each intelligence and strength. as a result of fish is omega-3 fatty acid fatty acids and macromolecule that helps regulate the heartbeat to traditional. And brain cells. it’s less fat, tasty, straightforward to digest for those that wish to contour the mechanism.

10th. feeding buggy as a habit. The beans square measure one in every of the foods you eat a day for two tablespoons a sweet dish. That square measure either free or macromolecule, vitamins and minerals essential for several varieties gathered to protest in these beans. ought to eat buggy frequently. I don’t eat plenty at a time. it’s high in calories. fat will cause.

If not absolutely accommodates all the recommendation higher than is nice health a habit to travel to waste!

About the Health Certification Board

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Digital Physiognomy – Religion & Spirituality

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